"Route 666"

Dean's past love re-enters his life in "Route 666," original air date Jan. 24, 2006.
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Cassie (Megalyn Echikunwoke), Dean (Jensen Ackles), and Sam (Jared Padalecki) are baffled by a string of murders.

Cassie, Dean, and Sam

(The WB)

Cassie (Megalyn Echikunwoke), Dean (Jensen Ackles), and Sam (Jared Padalecki) are baffled by a string of murders.